association between two single base polymorphisms of intercellular adhesion molecule 1 gene and inflammatory bowel disease
نویسندگان
چکیده
aim : the present study evaluated the association between g241r and k469e polymorphisms of intercellular adhesion molecule 1 gene and inflammatory bowel disease in iranian population. background : inflammatory bowel disease including ulcerative colitis and crohn’s disease, is a chronic idiopathic inflammatory disease of the gastrointestinal tract. there are two single base polymorphisms of intercellular adhesion molecule 1gene, g241r and k469e, reported to be associated with inflammatory disorders. patients and methods : in this case-control study, 156 inflammatory bowel disease patients (110 ulcerative colitis and 46 crohn’s disease patients) and 131 healthy controls were enrolled. two polymorphisms of intercellular adhesion molecule 1gene, including g241r and k469e, were assessed by polymerase chain reaction followed by restriction fragment length polymorphism. results : the e469 allele of k469e polymorphism was significantly more frequent in crohn’s disease patients compared to controls (p< 0.05, or= 1.83; 95% ci: 1.13 to 2.96). the mutant homozygote genotype of k469e polymorphism (e/e) was also significantly more frequent in crohn’s disease patients compared to controls (p< 0.05, or= 4.23; 95% ci: 1.42 to 12.59). no difference was observed in the frequency of k469e polymorphism among ulcerative colitis patients compared to controls. there were no significant differences in genotype and allele frequencies of g241r polymorphism among ulcerative colitis and crohn’s disease patients compared to control subjects. conclusion : according to our findings, k469e polymorphism of intercellular adhesion molecule 1 gene may probably participate in the pathogenesis of crohn’s disease in iran.
منابع مشابه
Association between two single base polymorphisms of intercellular adhesion molecule 1 gene and inflammatory bowel disease
AIM The present study evaluated the association between G241R and K469E polymorphisms of intercellular adhesion molecule 1 gene and inflammatory bowel disease in Iranian population. BACKGROUND Inflammatory bowel disease including ulcerative colitis and Crohn's disease, is a chronic idiopathic inflammatory disease of the gastrointestinal tract. There are two single base polymorphisms of interc...
متن کاملIntercellular adhesion molecule 1 gene polymorphisms in inflammatory bowel disease.
Intercellular adhesion molecule (ICAM)-1 is a single-chain cell surface glycoprotein that plays an important role in the recruitment of leukocytes at sites of inflammation and is up-regulated in intestinal mucosa of inflammatory bowel disease (IBD). ICAM-1 gene lies on chromosome 19p13, implicated in determining susceptibility to IBD. The human ICAM-1 gene contains two polymorphic sites in codo...
متن کاملAssociation between K469E allele of intercellular adhesion molecule 1 gene and inflammatory bowel disease in a Japanese population.
BACKGROUND AND AIMS The genetic contribution to inflammatory bowel disease (IBD) is under investigation. Recent evidence indicates a significant linkage between a locus on chromosome 19p13 and IBD. We investigated the association between an intercellular adhesion molecule 1 gene (ICAM-1) polymorphism located on chromosome 19p13 and IBD in a Japanese population. METHODS We compared 207 Japanes...
متن کاملAssociation between K469E allele of intercellular adhesion molecule 1 gene and inflammatory bowel disease in different populations.
متن کامل
INFLAMMATORY BOWEL DISEASE Association between K469E allele of intercellular adhesion molecule 1 gene and inflammatory bowel disease in a Japanese population
Background and aims: The genetic contribution to inflammatory bowel disease (IBD) is under investigation. Recent evidence indicates a significant linkage between a locus on chromosome 19p13 and IBD. We investigated the association between an intercellular adhesion molecule 1 gene (ICAM-1) polymorphism located on chromosome 19p13 and IBD in a Japanese population. Methods: We compared 207 Japanes...
متن کاملintercellular adhesion molecule-1 (icam-1) polymorphisms and cancer risk: a meta-analysis.
intercellular adhesion molecule-1 (icam-1) lys469glu (k469e) polymorphism and gly 241arg (g241r) polymorphism might play important roles in cancer development and progression. however, the results of previous studies are inconsistent. the aim of this study was to evaluate the association between icam-1 k469e and g241r polymorphisms and the risk of cancer by meta-analysis.a comprehensive literat...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
gastroenterology and hepatology from bed to benchجلد ۹، شماره ۲، صفحات ۲۰۱۶-۹
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023